Recent studies have advanced the integration of Wire Arc Additive Manufacturing (WAAM) with structural optimization; however, fatigue criteria remain overlooked despite their critical role in components subjected to cyclic loading [1,2]. This research explores a structural optimization strategy that explicitly incorporates fatigue criteria to enable the design of resource-efficient components capable of withstanding time-varying loads. To this end, a two-level optimization methodology is proposed. The study is directed to components fabricated from WAAM ER70S-6 carbon steel and validated by optimizing two well-known benchmark geometries from the literature: an L-bracket and a cantilever beam.